|Product Overview:||Recombinant Human PDK2 with a His tag is expressed inBacteriaand column-purified.|
|Description:||PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.|
|Storage:||Store at -80°C.|
|Gene Name:||PDK2 pyruvate dehydrogenase kinase, isozyme 2 [ Homo sapiens ]|
|Synonyms:||PDK2; pyruvate dehydrogenase kinase, isozyme 2; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial; PDHK2; EC 220.127.116.11|
|Pathway:||Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle|
|Function:||ATP binding; nucleotide binding; protein heterodimerization activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; protein homodimerization activity; transferase activity; two-component sensor activity|
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