"PDK2" Related Products


Recombinant Human PDK2, His-tagged

Cat. No.: PDK2-651H
Product Overview: Recombinant Human PDK2 with a His tag is expressed inBacteriaand column-purified.
Description: PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.
Source: Bacteria.
Storage: Store at -80°C.
Gene Name: PDK2 pyruvate dehydrogenase kinase, isozyme 2 [ Homo sapiens ]
Synonyms: PDK2; pyruvate dehydrogenase kinase, isozyme 2; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial; PDHK2; EC
Gene ID: 5164
mRNA Refseq: NM_002611
Protein Refseq: NP_002602
MIM: 602525
UniProt ID: Q15119
Chromosome Location: 17q21.33
Pathway: Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle
Function: ATP binding; nucleotide binding; protein heterodimerization activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; protein homodimerization activity; transferase activity; two-component sensor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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