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Recombinant Human Chemokine (C-C motif) Ligand 4

Cat.No. : CCL4-159H
Product Overview : Recombinant human macrophage inflammatory protein-1β was expressed inS. frugiperdainsect cells. A low molecular weight chemokine involved in inflammation, hematopoiesis, and immunoregulation. Exhibits chemoattractant activity on monocytes and chemoattractant and proadhesive effects on lymphocytes. MW = 7800.
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Cat. No. : CCL4-159H
Description : Macrophage Inflammatory Proteins belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1a and MIP-1b that are now also named CCL3 and CCL4. Both factors are produced by macrophages after they are stimulated with bacterial endotoxins. MIP-1a and MIP-1b activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. MIP-1a and MIP-1b induce synthesis and release of other pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-6 and TNF-alpha from fibroblasts and macrophages. CCL3 and CCL4 genes are both located on human chromosome 17.
Source : S. frugiperda.
Purity : ≥97% by SDS-PAGE.
Form : Lyophilized from sterile-filtered 30% acetonitrile, 0.1% TFA, 50 µg BSA/µg MIP-1β.
Biological activity : ED50 = 40-60 ng/ml as measured by its ability to inhibit mouse hematopoietic stem cell proliferation in an in vitro colony assay that detects primitive cells.
Endotoxin : ≤100 pg/µg MIP-1β.
Solubility : Sterile PBS containing ≥0.1% HSA or BSA.
Storage : ≤ -70°C.
Gene Name : CCL4 chemokine (C-C motif) ligand 4 [ Homo sapiens ]
Synonyms : CCL4; chemokine (C-C motif) ligand 4; ACT2; ACT-2; G-26; LAG1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MGC104418; MGC126025; MGC126026; MIP-1-beta; chemokine C-C motif ligand 4; CC chemokine ligand 4; secreted protein G-26; lymphocyte-activation gene 1; small inducible cytokine A4 (homologous to mouse Mip-1b); MIP-1-beta(1-69); HC21; LAG-1; LAG1; G-26 T-lymphocyte-secreted protein; Lymphocyte activation gene 1 protein; Macrophage inflammatory protein 1-beta; PAT 744; Protein H400; Small-inducible cytokine A4; T-cell activation protein 2; chemokine C-C motif ligand 4; ymphocyte-activation gene 1; small inducible cytokine A4 (homologous to mouse Mip-1b)
Gene ID : 6351
mRNA Refseq : NM_002984
Protein Refseq : NP_002975
MIM : 182284
UniProt ID : P13236
Chromosome Location : 17q12
Pathway : Cytokine-cytokine receptor interaction; Toll-like receptor signaling pathway
Function : chemokine activity; receptor signaling protein; tyrosine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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