Recombinant Human Cathepsin S
Cat.No. : | CTSS-750H |
Product Overview : | Recombinant, human cathepsin S was expressed inE. coliwithout a tag or fusion protein. MW = 24.5 kDa. |
- Specification
- Gene Information
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Cat. No. : | CTSS-750H |
Description : | A major lysosomal cysteine proteinase that is preferentially expressed in macrophages and microglia. Shown to be involved in the processing of antigenic peptides for presentation by MHC Class II molecules on the surface of antigen-presenting cells by mediating invariant (Ii) chain degradation. Inhibition of cathepsin S results in impaired antigen-presentation. |
Source : | E.coli. |
Purity : | ≥90% by SDS-PAGE. |
Form : | Liquid. In 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5. |
Specific Activity : | ≥30,000 mU/mg protein. |
Unit Definition : | One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit. |
Toxicity : | Harmful (MSDS available upon request). |
Storage : | ≤ -70℃. Avoid freeze/thaw. Following initial thaw, aliquot and freeze (-70℃). |
Gene Name : | CTSS cathepsin S [ Homo sapiens ] |
Synonyms : | CTSS; cathepsin S; MGC3886; Cathepsin S;EC 3.4.22.27; OTTHUMP00000032942 |
Gene ID : | 1520 |
mRNA Refseq : | NM_004079 |
Protein Refseq : | NP_004070 |
MIM : | 116845 |
UniProt ID : | P25774 |
Chromosome Location : | 1q21 |
Pathway : | Antigen processing and presentation; Lysosome |
Function : | cysteine-type endopeptidase activity; peptidase activity |
Products Types
◆ Recombinant Protein | ||
CTSS-1329R | Recombinant Rat CTSS Protein, His (Fc)-Avi-tagged | +Inquiry |
Ctss-1293R | Recombinant Rat Ctss Protein, His-tagged | +Inquiry |
CTSS-2118H | Recombinant Human CTSS Protein, GST-tagged | +Inquiry |
CTSS-1670R | Recombinant Rat CTSS Protein | +Inquiry |
Ctss-69M | Recombinant Mouse Ctss Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
CTSS-27405TH | Native Human CTSS | +Inquiry |
◆ Lysates | ||
CTSS-3021HCL | Recombinant Human CTSS cell lysate | +Inquiry |
CTSS-1563MCL | Recombinant Mouse CTSS cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-2353 | Cathepsin S Inhibitor Screening Kit (Fluorometric) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe function of CTSS proteins can be studied through gene knockout or knockdown techniques, such as using techniques such as CRISPR-Cas9 or RNAi. These techniques can create cellular models of missing or reduced CTSS proteins to observe their effects on cell death, among other things.
Expression level of CTSS protein can be detected by immunohistochemistry, western blotting, and real-time quantitative PCR.
CTSS proteins promote cell death by degrading proteins inside cells. During apoptosis, CTSS proteins degrade key proteins within cells, leading to cell death.
The interaction between CTSS proteins and other proteins is regulated by the formation of complexes or the regulation of signal transduction pathways. These interactions can be influenced by a variety of factors, such as ion concentrations, neurotransmitters, and growth factors.
Some studies have shown that the expression level of CTSS protein may be associated with the onset and progression of certain diseases. For example, in some cancers, the expression level of the CTSS protein may change.
It is mainly expressed in lysosomes, which is one of the major proteases in lysosomes.
Customer Reviews (3)
Write a reviewHigh catalytic efficiency, short time, saving time.
The solubility is very good and can be easily dissolved in various buffers.
Anti-pollution ability is very strong, not easy to be polluted.
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