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Recombinant Human Cathepsin S

Cat.No. : CTSS-750H
Product Overview : Recombinant, human cathepsin S was expressed inE. coliwithout a tag or fusion protein. MW = 24.5 kDa.
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Cat. No. : CTSS-750H
Description : A major lysosomal cysteine proteinase that is preferentially expressed in macrophages and microglia. Shown to be involved in the processing of antigenic peptides for presentation by MHC Class II molecules on the surface of antigen-presenting cells by mediating invariant (Ii) chain degradation. Inhibition of cathepsin S results in impaired antigen-presentation.
Source : E.coli.
Purity : ≥90% by SDS-PAGE.
Form : Liquid. In 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.
Specific Activity : ≥30,000 mU/mg protein.
Unit Definition : One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.
Toxicity : Harmful (MSDS available upon request).
Storage : ≤ -70℃. Avoid freeze/thaw. Following initial thaw, aliquot and freeze (-70℃).
Gene Name : CTSS cathepsin S [ Homo sapiens ]
Synonyms : CTSS; cathepsin S; MGC3886; Cathepsin S;EC 3.4.22.27; OTTHUMP00000032942
Gene ID : 1520
mRNA Refseq : NM_004079
Protein Refseq : NP_004070
MIM : 116845
UniProt ID : P25774
Chromosome Location : 1q21
Pathway : Antigen processing and presentation; Lysosome
Function : cysteine-type endopeptidase activity; peptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How can the function of CTSS proteins be studied by gene knockout or knockdown techniques? 04/17/2022

The function of CTSS proteins can be studied through gene knockout or knockdown techniques, such as using techniques such as CRISPR-Cas9 or RNAi. These techniques can create cellular models of missing or reduced CTSS proteins to observe their effects on cell death, among other things.

How can I detect the expression level of CTSS protein? 02/05/2022

Expression level of CTSS protein can be detected by immunohistochemistry, western blotting, and real-time quantitative PCR.

How is CTSS protein involved in the process of apoptosis? 10/06/2021

CTSS proteins promote cell death by degrading proteins inside cells. During apoptosis, CTSS proteins degrade key proteins within cells, leading to cell death.

Are the interactions between CTSS proteins and other proteins regulated? 05/04/2021

The interaction between CTSS proteins and other proteins is regulated by the formation of complexes or the regulation of signal transduction pathways. These interactions can be influenced by a variety of factors, such as ion concentrations, neurotransmitters, and growth factors.

What is the relationship between the expression level of CTSS protein and the occurrence and progression of diseases? 02/08/2021

Some studies have shown that the expression level of CTSS protein may be associated with the onset and progression of certain diseases. For example, in some cancers, the expression level of the CTSS protein may change.

In which organelles is CTSS protein expressed? 09/18/2020

It is mainly expressed in lysosomes, which is one of the major proteases in lysosomes.

Customer Reviews (3)

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Reviews
11/01/2021

    High catalytic efficiency, short time, saving time.

    06/13/2021

      The solubility is very good and can be easily dissolved in various buffers.

      03/27/2021

        Anti-pollution ability is very strong, not easy to be polluted.

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