Recombinant Human CHEK2, His-tagged CHEK2-686H

Recombinant Human CHEK2, His-tagged

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Recombinant Human CHEK2, His-tagged

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Cat. No. : CHEK2-686H
Product Overview : Recombinant human checkpoint homologue kinase 2 (Chk2) fused to a His Tag sequence at the N-terminus was expressed inS. frugiperdainsect cells. MW = 65430 Da.
Description : Chk2 is involved in sensing DNA damage in eukaryotic cells. It plays an important role in the control of the cell cycle by blocking replication.
Source : S. frugiperda.
Form : Liquid. In 270 mM sucrose, 150 mM NaCl, 50 mM Tris-HCl, 1 mM DTT, 0.1 mM EGTA, pH 7.5. Please refer to vial label for lot-specific concentration.
Specific Activity : ≥ 25,000 units/mg protein.
Purity : ≥ 95% by SDS PAGE.
Unit Definition : One unit is defined as the amount of enzyme required to transfer 1 picomol phosphate to the synthetic peptide substrate KKKVSRSGLYRSPSMPENLNRPR per min at 30°C.
Toxicity : Standard Handling (MSDS available upon request).
Storage : ≤ -70 °C. Avoid freeze/thaw Following initial thaw, aliquot and freeze (-70°C).
Gene Name : CHEK2 CHK2 checkpoint homolog (S. pombe) [ Homo sapiens ]
Synonyms : CHEK2; CHK2 checkpoint homolog (S. pombe); CDS1; CHK2; LFS2; RAD53; HuCds1; PP1425; CHK2 (checkpoint, S.pombe) homolog; Serine/threonine-protein kinase Chk2; EC 2.7.11.1; Cds1
Gene ID : 11200
mRNA Refseq : NM_001005735
Protein Refseq : NP_001005735
MIM : 604373
UniProt ID : O96017
Chromosome Location : 22q12.1
Pathway : Cell cycle; p53 signaling pathway; Cell Cycle Checkpoints
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity; magnesium ion binding; protein binding

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