Recombinant Human Cell Division Cycle 25 Homolog C (S. Pombe)

• Cat.No.: CDC25C-699H
• Product Overview: Recombinant Human Cell Division Cycle 25 Homolog C (S. Pombe) is expressed inE.coli.

Specification

• Cat. No.: CDC25C-699H
• Description: Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant. As with other cell cycle proteins such as Cdc2 and Cdc4, the "cdc" in its name refers to "cell division cycle". Dual-specificity phosphatases are considered a sub-class of protein tyrosine phosphatases. By removing inhibitory phosphate residues from target Cyclin-Dependent Kinases (Cdks, Cdc25 proteins control entry into and progression through various phases of the cell cycle, including mitosis and S ("Synthesis") phase.
• Source: E.coli.
• Purity: Greater than 90 % pure as determined by SDS-PAGE analysis.
• Molecular Weight: 48 kDa bandby SDS-PAGE analysis.
• Formulation: The recombinant Cdc25C (catalytic domain) is supplied frozen in a buffer containing 20mM Tris-HCl (pH 8.2), 1mM EDTA, 2 mM DTT and 50% glycerol.
• Storage: Stable for 12 months at -70°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot enzyme to avoid repeated freezing and thawing.

Gene Information

• Gene Name: CDC25C cell division cycle 25 homolog C (S. pombe) [ Homo sapiens ]
• Synonyms:
  CDC25C; cell division cycle 25 homolog C (S. pombe); M-phase inducer phosphatase 3; OTTHUMP00000159490; cell division cycle 25C; dual specificity phosphatase CDC25C; mitosis inducer CDC25; phosphotyrosine phosphatase; CDC25; EC 3.1.3.48
• Gene ID: 995
• mRNA Refseq: NM_001790
• Protein Refseq: NP_001781
• MIM: 157680
• UniProt ID: P30307
• Chromosome Location: 5q31
• Pathway: Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Cell Cycle Checkpoints; Cell Cycle, Mitotic
• Function: WW domain binding; hydrolase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity