|Cat. No. :
|Product Overview :
||Recombinant Human Annexin A5-PE is expressed inE. coli.
||Annexin 5 is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. In vitro studies have shown that Annexin 5 is a cellular protein which plays a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin. Through affinity assays Annexin 5 has been localized on cells that expressed phosphatidylserine on the cell surface, a feature found in apoptosis as well as other forms of cell death.
||>98% pure as demonstrated by SDS-gel electrophoresis and reverse phase HPLC.
|Molecular Weight :
||Solution containing 50 mM TRIS, 100 mM NaCl, 1% BSA, 0.02% Sodium Azide, pH 7.4.
|Biological Activity :
||Annexin V exhibits anti-phospholipase activity and binds to phosphatidylserine (PS).
||PE labelling allows simple direct detection of PS by FACS analysis. Counterstaining by propidium iodide allows the discrimination of apoptotic cells.
||Stable at 2°-8°C as indicated on the label. Do not freeze!