"APOE" Related Products

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Recombinant Human Apolipoprotein E, E2 Isoforms

Cat. No.: APOE-2630H
Product Overview: Recombinant human apolipoprotein E-E2 (cysteine at amino acids 112 and 158) expressed in S.frugiperda insect cellsusing a baculovirus expression system. Binds to β-amyloid protein but not to the LDL receptor. Does not compete with human low density lipoprotein for binding to the human Apo B/E (LDL) receptor.
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution.
Source: S. frugiperda insect cells.
Form: Liquid.
Formulation: In 700 mM NH4HCO3.
Molar Mass: 34000Da.
Purity: ≥95% by SDS-PAGE.
Storage: ≤ -70oC. Ship: Dry Ice Only.
Gene Name: APOE apolipoprotein E [ Homo sapiens ]
Synonyms:
APOE; apolipoprotein E; AD2; LPG; LDLCQ5; MGC1571; apolipoprotein E3; Apo-E
Gene ID: 348
mRNA Refseq: NM_000041
Protein Refseq: NP_000032
MIM: 107741
UniProt ID: P02649
Chromosome Location: 19q13.31
Pathway: Alzheimer"s disease; Metabolism of lipids and lipoproteins
Function: antioxidant activity; beta-amyloid binding; cholesterol transporter activity; lipid transporter activity; low-density lipoprotein receptor binding; phosphatidylcholine-sterol O-acyltransferase activator activity; protein heterodimerization activity; very-low-density lipoprotein receptor binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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