"RB1" Related Products


Recombinant Human RB1, GST-tagged

Cat.No. : RB1-570H
Product Overview : Recombinant Human RB1, fused with N-terminal GST tag, was expressed in an E. coli expression system.
Description : The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Source : E. coli
Species : Human
Tag : GST
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 18 mM Glutathione, 10% glycerol, and 3 mM DTT.
Molecular Mass : 43.5 kDa
Purity : ≥ 47%
Applications : Kinase substrate for the kinase assay; western blot
Storage : >6 months at –80°C
Gene Name : RB1 retinoblastoma 1 [ Homo sapiens ]
Official Symbol : RB1
Synonyms : RB1; retinoblastoma 1; RB; pRb; OSRC; pp110; p105-Rb; RB1; osteosarcoma; OTTHUMP00000018397; Rb; retinoblastoma suspectibility protein; retinoblastoma-associated protein
Gene ID : 5925
mRNA Refseq : NM_000321
Protein Refseq : NP_000312
MIM : 180200
UniProt ID : P06400
Chromosome Location : 13q14.2
Pathway : Bladder cancer; Cell cycle; Chronic myeloid leukemia; Glioma; Melanoma; Non-small cell lung cancer; Pancreatic cancer;
Function : androgen receptor binding; kinase binding; phosphoprotein binding; transcription coactivator activity; transcription factor activity; transcription factor binding; transcription repressor activity; ubiquitin protein ligase binding

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