|Product Overview:||Recombinant Human QPRT was produced inE.coliwith a T7 tag at N-terminus. MW = 30816 Da (1-297 aa).|
|Description:||This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer"s disease, and Huntington"s disease.|
|Form:||10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.|
|Gene Name:||QPRT quinolinate phosphoribosyltransferase [ Homo sapiens ]|
|Synonyms:||QPRT; quinolinate phosphoribosyltransferase; QPRTase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; nicotinate-nucleotide pyrophosphorylase (carboxylating); EC 18.104.22.168; nicotinate-nucleotide pyrophosphorylase|
|Pathway:||Metabolic pathways; Nicotinate and nicotinamide metabolism|
|Function:||nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity; transferase activity, transferring glycosyl groups|
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