"RAB3B" Related Products

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Recombinant Human RAB3B, T7-tagged

Cat. No.: RAB3B-2976H
Product Overview: Recombinant Human RAB3B (1-219 aa) is expressed in E.Coli with a T7 tag at N-terminus.
Description: In Parkinson"s disease (PD), dopaminergic (DA) neurons in the substantia nigra (SN, A9) are particularly vulnerable, compared to adjacent DA neurons within the ventral tegmental area (VTA, A10). Here, we show that in rat and human, one RAB3 isoform, RAB3B, has higher expression levels in A10 compared to A9 neurons. RAB3 is a monomeric GTPase protein that is highly enriched in synaptic vesicles and is involved in synaptic vesicle trafficking and synaptic transmission, disturbances of which have been implicated in several neurodegenerative diseases, including PD.
Source: E.Coli.
MW: 24758 Da.
Purity: 95%.
Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100.0.002% NaN3.
Application: MS. SDS.
Gene Name: RAB3B RAB3B, member RAS oncogene family [ Homo sapiens ]
Synonyms: RAB3B; RAB3B, member RAS oncogene family;brain antigen RAB3B; ras-related protein Rab-3B; RAB3B, member RAS oncogene family
Gene ID: 5865
mRNA Refseq: NM_002867
Protein Refseq: NP_002858
MIM: 179510
UniProt ID: P20337
Chromosome Location: 1p32-p31
Pathway: Tight junction
Function: GTP binding; GTPase activity; nucleotide binding; protein binding

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