Recombinant Human MAPK Scaffold Protein 1, His-tagged

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Recombinant Human MAPK Scaffold Protein 1, His-tagged

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Cat. No. : MAPKSP1-937H
Product Overview : Recombinant human MAPKSP1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 15.8kDa (144aa).
Description : MAPKSP1 (Mitogen-activated protein kinase scaffold protein 1) is a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2.
Source : E.coli.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 5mM DTT, 100mM NaCl.
Purity : > 95% by SDS - PAGE.
Concentration : 0.5mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : GSSHHHHHH SSGLVPRGSH MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIK VANDNA PEHALRPGFL STFALATDQG SKLGLSKNKSIICYYNTYQV VQFNRLPLVV SFIASSSANT GLIVSLEKEL APLFEELRQV VEVS.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : MAPK signaling pathway
PDB rendering based on 1sko. :

Gene Name : MAPKSP1 MAPK scaffold protein 1 [ Homo sapiens ]
Synonyms : MAPK scaffold protein 1; MP1; MAPBP; MAP2K1IP1; MAPKSP1; PRO0633; mitogen-activated protein kinase scaffold protein 1; MEK partner 1; OTTHUMP00000219461; MEK binding partner 1; MEK-binding partner 1; mitogen-activated protein kinase kinase 1 interacting protein 1; mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mp1
Gene ID : 8649
mRNA Refseq : NM_021970
Protein Refseq : NP_068805
MIM : 603296
UniProt ID : Q9UHA4
Chromosome Location : 4q23
Function : protein binding

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