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Recombinant Human Flavin Containing Monooxygenase 1

Cat. No.: FMO1-719H
Description: Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene. Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in xenobiotics such as pesticides and drugs.
Source: baculovirus infected insect cells.
Biochem/physiol Actions: The FMO's are responsible for catalyzing the oxygenation of a variety of xenobiotic and drug compounds including environmental pollutants and carcinogens which contain a nucleophilic nitrogen, sulfur, selenium, or phosphorus-containing moiety associated with their respective oxides. These enzymes are classified as Phase I or oxidative drug metabolism enzymes.
Physical Form: Solution in 100 mM potassium phosphate buffer, pH 7.4.
Form: buffered aqueous solution.
Storage Temp: -70°C.
Gene Name: FMO1 flavin containing monooxygenase 1 [ Homo sapiens ]
Synonyms: flavin containing monooxygenase 1; FMO1; dimethylaniline monooxygenase [N-oxide-forming] 1; FMO 1; OTTHUMP00000033537; dimethylaniline oxidase 1; Flavin-containing monooxygenase 1 (fetal liver); fetal hepatic flavin-containing monooxygenase 1;Dimethylaniline oxidase 1; Fetal hepatic flavin-containing monooxygenase 1; EC 1.14.13.8
Gene ID: 2326
mRNA Refseq: NM_002021
Protein Refseq: NP_002012
MIM: 136130
UniProt ID: Q01740
Chromosome Location: 1q23-q25
Pathway: Drug metabolism - cytochrome P450; Biological oxidations
Function: FAD binding; NADP or NADPH binding; binding; flavin-containing monooxygenase activity; monooxygenase activity

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