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Recombinant Human MAPKAPK2

Cat.No. : MAPKAPK2-670H
Product Overview : Recombinant human MAPKAPK2 (46-end) was expressed inHEK 293 cells.
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  • Gene Information
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Cat. No. : MAPKAPK2-670H
Description : MAPKAPK2 is a serine/threonine protein kinase activated by the p38 MAP kinase in response to various signals including mitogenic and stress stimuli. MAPKAPK2 is distinguished from the RSK family of ribosomal protein S6 kinases (also termed MAPKAPK1), which are activated by the MAP kinases, ERK1, and ERK2 based on its substrate specificity and amino acid sequence. Upon activation, p38 MAP kinase activates the downstream MAPKAPK2 by phosphorylation of the threonine residue in the Pro-Thr motif in response to heat shock or mitogenic stimuli. Activated MAPKAPK2 phosphorylates the small heat shock protein HSP25/HSP27, both in vitro and in vivo, at serine residues. Thus, HSP25/HSP27 seems to be the physiological substrate of MAPKAPK2.
Source : HEK 293 cells.
Unit Definition : One unit will incorporate 1.0 nmole of phosphate into HSP 25 per minute at 30 °C at pH 7.4.
Physical Form : Solution in 50 mM Tris-HCl, pH 7.4, 100 mM NaCl, 0.05 mM EDTA, 2 mM DTT, and 10% glycerol.
Form : Buffered aqueous glycerol solution.
Storage : −70°C. Shipped in dry ice.
Gene Name : MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 [ Homo sapiens ]
Synonyms :
MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2; MK2; EC 2.7.11.1; MAPKAP kinase 2; MAPKAPK-2
Gene ID : 9261
mRNA Refseq : NM_004759
Protein Refseq : NP_004750
MIM : 602006
UniProt ID : P49137
Chromosome Location : 1q32
Pathway : MAPK signaling pathway; Neurotrophin signaling pathway; VEGF signaling pathway; Signalling by NGF
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; signal transducer activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What structural features of MAPKAPK2 are critical for its kinase activity, and how do these features influence its interactions with substrates and regulatory partners? 05/11/2022

MAPKAPK2's kinase activity is influenced by its structural features, including the catalytic domain. These features determine substrate interactions and regulatory partnerships, providing insights into its molecular functions.

What is known about the role of MAPKAPK2 in the immune response, particularly in the regulation of cytokine production and immune cell functions? 06/29/2020

MAPKAPK2 plays a role in the immune response by regulating cytokine production and immune cell functions. It influences the activity of transcription factors involved in immune-related gene expression.

How does MAPKAPK2 contribute to cellular motility, and what molecular mechanisms are involved in its regulation of the cytoskeleton and cell migration? 12/17/2019

MAPKAPK2 regulates cellular motility by influencing the cytoskeleton and cell migration. It phosphorylates proteins involved in cytoskeletal dynamics, impacting cell motility and invasive behavior.

Can you elaborate on the regulatory mechanisms controlling MAPKAPK2 activation and its substrate specificity? 01/15/2019

MAPKAPK2 activation is regulated by p38 MAP kinase through phosphorylation. Its substrate specificity is determined by specific phosphorylation motifs, and its activity is influenced by interacting proteins.

In cancer research, how is MAPKAPK2 implicated in tumor development and progression, and are there potential therapeutic strategies targeting this kinase? 04/18/2018

MAPKAPK2 has been associated with tumor development and progression. Understanding its role in cancer biology may lead to the development of targeted therapies, although challenges exist in achieving specificity.

Customer Reviews (3)

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Reviews
04/15/2022

    The lab product sets a new standard for quality. Delivery was speedy, and the customer service team was exceptionally helpful.

    11/23/2020

      Reliable product, friendly customer service, and efficient delivery.

      08/06/2019

        Precision in quality, responsive customer service, and fast, secure delivery

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