"PTPRF" Related Products

Recombinant Human PTPRF, Catalytic Domain

Cat. No. : PTPRF-714H
Product Overview : Recombinant human PTPRF was expressed inE.Coli.
Description : PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
Source : E.Coli.
Biochem/Physiol Actions : LAR, a leukocyte antigen related protein, is a transmembrane receptor-like protein tyrosine phosphatase (PTPase). Its cytoplasmic domain comprises two tandem domains possessing PTPase homology. Only one domain, LAR-D1, has phosphatase activity.
Analysis Note : LAR-D1 catalytic domain comprises amino acids 1275-1613.
Physical Form : Solution containing 10 mM imidazole, pH 7.0, 2 mM EDTA, 5 mM DTT, 0.1 M NaCl, and 50% glycerol.
Assay : ≥95% (SDS-PAGE).
Form : Buffered aqueous glycerol solution.
Storage Temp : −70°C.
PDB rendering based on 1lar. :

Gene Name : PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens ]
Synonyms : PTPRF; protein tyrosine phosphatase, receptor type, F; LCA-homolog; OTTHUMP00000008683; OTTHUMP00000008684; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; LAR; FLJ43335; FLJ45062; FLJ45567; EC 3.1.3.48
Gene ID : 5792
mRNA Refseq : NM_002840
Protein Refseq : NP_002831
MIM : 179590
UniProt ID : P10586
Chromosome Location : 1p34
Pathway : Adherens junction; Cell adhesion molecules (CAMs); Insulin signaling pathway
Function : heparan sulfate proteoglycan binding; heparin binding; hydrolase activit; protein binding; protein kinase binding; transmembrane receptor protein tyrosine phosphatase activity

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