Recombinant Human ANGPT2, Flag-tagged ANGPT2-435H

Recombinant Human ANGPT2, Flag-tagged


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Recombinant Human ANGPT2, Flag-tagged

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Cat.No. : ANGPT2-435H
Product Overview : Recombinant Human ANGPT2(aa 19-496), fused at the N-terminus to a FLAG®-tag, was expressed in HEK 293 cells.
Description : The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
Source : HEK 293 cells
Species : Human
Tag : Flag
Form : Lyophilized. Contains PBS with trehalose and Brij35.
Bio-activity : Binds to the human and mouse Tie-2 receptor.
Molecular Mass : ~70kDa (SDS-PAGE)
Endotoxin : <0.01EU/μg purified protein (LAL test; Lonza).
Purity : ≥95% (SDS-PAGE)
Storage : Short Term Storage: +4°CLong Term Storage: -20°CHandling Advice: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Concentration : 0.1 mg /ml after reconstitution.
Reconstitution : Reconstitute with 100μl sterile water.
Gene Name : ANGPT2 angiopoietin 2 [ Homo sapiens ]
Official Symbol : ANGPT2
Synonyms : ANGPT2; angiopoietin 2; ANG2; AGPT2; Tie2-ligand; angiopoietin-2B;.angiopoietin-2a; angiopoietin-2; ANG-2
Gene ID : 285
mRNA Refseq : NM_001118887
Protein Refseq : NP_001112359
MIM : 601922
UniProt ID : O15123
Chromosome Location : 8p23.1
Pathway : Angiopoietin receptor Tie2-mediated signaling; Cell surface interactions at the vascular wall; HIF-1 signaling pathway
Function : metal ion binding; protein binding; receptor binding; receptor tyrosine kinase binding

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