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Official Full Name angiopoietin 2
Background The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms ANGPT2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a
    • Species :
    • Canine
    • Cattle
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Cynomolgus, Rhesus
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • CHO
    • CHO Stable Cells
    • E.coli
    • Hamster
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • Flag
    • GST
    • His
    • T7
    • His-Avi
    • MlgG2a Fc
    • MYC
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human Ang-2-3456H Recombinant Human Ang-2 CHO N/A
    Human ANGPT2-1067H Recombinant Human ANGPT2 Protein (Met1-Gln248 and Lys275-Phe496), MlgG2a Fc-tagged HEK293 MlgG2a Fc
    Human ANGPT2-116H Recombinant Human Angiopoietin 2, Myc-tagged Insect Cell MYC
    Human ANGPT2-158H Recombinant Human ANGPT2 Protein, His-tagged, Biotinylated NS0 His
    Human ANGPT2-200H Recombinant Human ANGPT2, Fc tagged Human Cell Fc
    Human ANGPT2-2228HCL Recombinant Human ANGPT2 cell lysate Human Cell N/A
    Human ANGPT2-244H Recombinant Human ANGPT2 protein, His-tagged HEK293 His
    Human ANGPT2-269H Recombinant Human ANGPT2, His-tagged, Biotinylated HEK293 His
    Human ANGPT2-3182H Recombinant Human ANGPT2, His tagged Human Cell His
    Human ANGPT2-388H Recombinant Human ANGPT2 Protein, His-tagged CHO His
    Human ANGPT2-415H Recombinant Human ANGPT2 Protein (Met1-Phe496), His-tagged CHO His
    Human ANGPT2-415HB Recombinant Human ANGPT2 protein, His-tagged, Biotinylated CHO Stable Cells His
    Human ANGPT2-435H Recombinant Human ANGPT2, Flag-tagged HEK293 Flag
    Human ANGPT2-523HB Recombinant Human ANGPT2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human ANGPT2-531H Recombinant Human ANGPT2 protein, His-tagged E.coli His
    Human ANGPT2-532H Recombinant Human ANGPT2 protein, His-tagged E.coli His
    Human ANGPT2-550H Recombinant Human ANGPT2 protein, His-tagged Hamster His
    Human ANGPT2-551H Recombinant Human ANGPT2 protein, GST-tagged Wheat Germ GST
    Human ANGPT2-55H Recombinant Human ANGPT2 Yeast N/A
    Human ANGPT2-6523H Recombinant Human ANGPT2 Protein, His-Avi-tagged HEK293 His-Avi
    Human ANGPT2-696H Recombinant Human ANGPT2 Protein, His-tagged CHO His
    Human ANGPT2-933H Recombinant Human ANGPT2 Protein, His-tagged NS0 His
    Human ANGPT2-934H Recombinant Human ANGPT2 Protein, His-tagged Protein, Biotinylated NS0 His
    Human ANGPT2-9645H Recombinant Human ANGPT2, GST-tagged E.coli GST
    Mouse ANGPT2-001MCL Recombinant Mouse ANGPT2 cell lysate Human Cell N/A
    Mouse Angpt2-2163M Recombinant Mouse Angiopoietin 2, His-tagged Mammalian Cell His
    Mouse Angpt2-475M Recombinant Mouse Angpt2, His-tagged Human Cell His
    Mouse Angpt2-476M Recombinant Mouse Angpt2 protein, His-tagged HEK293 His
    Mouse Angpt2-533M Recombinant Mouse Angpt2 protein, His-tagged E.coli His
    Mouse Angpt2-587M Recombinant Mouse Angpt2 Protein, His-tagged CHO His
    Mouse Angpt2-88M Recombinant Mouse Angpt2, FLAG-tagged HEK293 Flag
    Rat Angpt2-535R Recombinant Rat Angpt2 protein, His-tagged E.coli His
    Rat Angpt2-536R Recombinant Rat Angpt2 protein, His-tagged E.coli His
    Rat ANGPT2-669R Recombinant Rat ANGPT2 Protein Mammalian Cell His
    Cynomolgus Monkey ANGPT2-1172C Recombinant Cynomolgus ANGPT2 Protein, Fc-tagged HEK293 Fc
    Cynomolgus ANGPT2-1173C Recombinant Cynomolgus ANGPT2 Protein, His-tagged HEK293 His
    Canine ANGPT2-1040C Recombinant Canine ANGPT2 Protein, His-tagged HEK293 His
    Rabbit ANGPT2-315R Recombinant Rabbit ANGPT2 protein, His-tagged HEK293 His
    Rabbit ANGPT2-537R Recombinant Rabbit ANGPT2 protein, His-tagged E.coli His
    Chicken ANGPT2-6380C Recombinant Chicken ANGPT2 Mammalian Cell His
    Cynomolgus, Rhesus ANGPT2-1174C Recombinant Cynomolgus/Rhesus ANGPT2 protein (Met1-Phe495), His-tagged HEK293 His
    Cattle ANGPT2-530C Recombinant Cattle ANGPT2 protein, His-tagged E.coli His
    Pig ANGPT2-534P Recombinant Pig ANGPT2 protein, His & T7-tagged E.coli His/T7

    angpt2 involved in several pathways and played different roles in them. We selected most pathways angpt2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with angpt2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway VEGFC; FGF17; GAB2; PIK3R2; RAPGEF5; GNGT2; FLT1; RASSF5; FGFR2; CSF1
    Rap signaling pathway FGF4; PIK3CD; Fgf15; MAP2K1; RAP1B; CALML3; MAP2K3; RAC2; VAV2; MAPK13
    HIF- signaling pathway STAT3; GM5506; VEGFA; NOS2; IGF1; MAP2K2; CAMK2G; HK2; VHL; PIK3R5
    PIK-Akt signaling pathway THBS2; TRP53; FGF9; GNG4; CRTC2; PPP2R2D; VEGFB; ITGA3; LPAR2; FGFR1

    angpt2 has several biochemical functions, for example, metal ion binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by angpt2 itself. We selected most functions angpt2 had, and list some proteins which have the same functions with angpt2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding ENDOU2; FBXO40.1; GIT2; ALKBH5; PATZ1; LMAN2L; IKZF3; ERI1; ARHGAP29; PDE5A
    protein binding BABAM1; FATE1; FNBP4; SMCP; PLEKHG6; IFI30; SPINK1; RANBP2; STAC; APOBEC2A
    receptor binding WNT5B; MAG; ITGA1; DAO1; LRP6; Ifnl2; FGF1B; IAPP; WNT2BA; PVRL3B
    receptor tyrosine kinase binding PTPN14; PLCG1; PIK3R2; LRP4; ANGPT2A; NCK1; ZFP259; GNB2L1; SHC3; ARHGEF16

    angpt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with angpt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of angpt2.

    daap-5; TEK; daap-4; VEGFA; ANXA7; CDKN1A; CSNK2B; IQCB1

    Rigamonti, N; Kadioglu, E; et al. Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade. CELL REPORTS 8:696-706(2014).
    D'Amico, G; Korhonen, EA; et al. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. JOURNAL OF CLINICAL INVESTIGATION 124:824-834(2014).

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