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Recombinant Human COCH, His tagged

Cat.No. : COCH-3207H
Product Overview : Recombinant Human COCH (NP_001128530.1) mature form (Glu 25-Gln 550), fused with a polyhistidine tag at the N-terminus, was produced in Human Cell.
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Source : Human Cells
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4
Molecular Mass : The recombinant full length of human COCH consists of 542 amino acids and has a calculated molecular mass of 59.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCOCH is approximately 18 kDa, corresponding to the alternative splicing short isoform, whivch lacks two VWFA domains.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : COCH coagulation factor C homolog, cochlin (Limulus polyphemus) [ Homo sapiens ]
Official Symbol : COCH
Gene ID : 1690
mRNA Refseq : NM_001135058
Protein Refseq : NP_001128530
MIM : 603196
UniProt ID : O43405

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do genetic mutations in the COCH gene affect hearing and balance? 03/03/2023

Mutations in COCH can lead to impaired cochlear function, resulting in hearing and balance disorders.

How does COCH contribute to the maintenance of cochlear structure and function? 01/06/2023

It plays a key role in the structural integrity and mechanical properties of the cochlear extracellular matrix.

How does COCH interact with other proteins in the cochlea to support hearing? 09/28/2022

COCH works with other cochlear proteins to maintain the mechanics and signal transduction necessary for hearing.

What potential therapeutic approaches could target COCH for treating hearing loss? 06/04/2022

Therapeutic strategies targeting COCH could offer new treatments for genetic and age-related hearing loss.

What is the impact of COCH dysfunction in age-related hearing loss? 07/08/2021

COCH dysfunction is associated with the progression of age-related hearing loss, affecting cochlear homeostasis.

What is the primary function of COCH in the inner ear and hearing process? 01/16/2019

COCH is essential for maintaining the structure and function of the cochlea, crucial for hearing.

What role does COCH play in the development and progression of hearing loss disorders? 04/07/2018

COCH dysfunctions are closely linked to various types of hearing loss, including sensorineural hearing loss.

Customer Reviews (3)

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07/28/2020

    Key contributor to our research discoveries.

    05/24/2018

      Swift and accurate service, a research necessity.

      11/03/2017

        Invaluable support for our protein experiments.

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