Recombinant Human CRKL, His-tagged
Cat.No. : | CRKL-3373H |
Product Overview : | Recombinant human CRKL protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 35.9 kDa (323aa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | CRKL-3373H |
Description : | CRKL is a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substitutete of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and has oncogenic potential. |
Source : | E.coli. |
Form : | Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl. |
Purity : | > 90% by SDS - PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD ENE. |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | Bacterial invasion of epithelial cells; Chemokine signaling pathway; Chronic myeloid leukemia; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Insulin signaling pathway; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; Shigellosis; Signaling by PDGF |
Gene Name : | CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like [ Homo sapiens ] |
Synonyms : | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; CRKL; crk-like protein; OTTHUMP00000198539; v-crk avian sarcoma virus CT10 oncogene homolog-like |
Gene ID : | 1399 |
mRNA Refseq : | NM_005207 |
Protein Refseq : | NP_005198 |
MIM : | 602007 |
UniProt ID : | P46109 |
Chromosome Location : | 22q11; 22q11.21 |
Function : | SH3/SH2 adaptor activity; protein binding; protein tyrosine kinase activity; signal transducer activity |
Products Types
◆ Recombinant Protein | ||
CRKL-856R | Recombinant Rhesus Macaque CRKL Protein, His (Fc)-Avi-tagged | +Inquiry |
CRKL-1889H | Recombinant Human CRKL Protein, GST-tagged | +Inquiry |
CRKL-0644H | Recombinant Human CRKL Protein (M1-E303), Tag Free | +Inquiry |
Crkl-2314M | Recombinant Mouse Crkl Protein, Myc/DDK-tagged | +Inquiry |
CRKL-3324H | Recombinant Human CRKL Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
CRKL-403HCL | Recombinant Human CRKL cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket