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Recombinant Human CRKL, His-tagged

Cat. No.: CRKL-3373H
Product Overview: Recombinant human CRKL protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 35.9 kDa (323aa).
Description: CRKL is a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substitutete of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and has oncogenic potential.
Source: E.coli.
Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.
Purity: > 90% by SDS - PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD ENE.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Bacterial invasion of epithelial cells; Chemokine signaling pathway; Chronic myeloid leukemia; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Insulin signaling pathway; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; Shigellosis; Signaling by PDGF
Gene Name: CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like [ Homo sapiens ]
Synonyms: v-crk sarcoma virus CT10 oncogene homolog (avian)-like; CRKL; crk-like protein; OTTHUMP00000198539; v-crk avian sarcoma virus CT10 oncogene homolog-like
Gene ID: 1399
mRNA Refseq: NM_005207
Protein Refseq: NP_005198
MIM: 602007
UniProt ID: P46109
Chromosome Location: 22q11; 22q11.21
Function: SH3/SH2 adaptor activity; protein binding; protein tyrosine kinase activity; signal transducer activity

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