"DCTD" Related Products

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Recombinant Human dCMP Deaminase, His-tagged

Cat. No.: DCTD-732H
Product Overview: Recombinant human DCTD protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 22.1 kDa (198aa).
Description: DCTD (deoxycytidylate deaminase), also known as dCMP deaminase, is a 178 amino acid allosteric enzyme that exists as a homohexamer and belongs to the cytidine and deoxycytidylate deaminase protein family. Using zinc as a cofactor, DCTD catalyzes the deamination of dCMP to dUMP, thereby producing the nucleotide substrate (dUMP) that is used by thymidylate synthase.
Source: E.coli.
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MSEVSCKKRD DYLEWPEYFM AVAFLSAQRS KDPNSQVGAC IVNSENKIVG IGYNGMPNGC SDDVLPWRRT AENKLDTKYP YVCHAELNAI MNKNSTDVKG CSMYVALFPC NECAKLIIQA GIKEVIFMSD KYHDSDEATA ARLLFNMAGV TFRKFIPKCS KIVIDFDSIN SRPSQKLQ
Purity: > 90% by SDS – PAGE.
Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 1mM DTT, 20% glycerol.
Concentration: 0.5 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: DCTD dCMP deaminase [ Homo sapiens ]
Synonyms: DCTD; dCMP deaminase; MGC111062; deoxycytidylate deaminase; EC 3.5.4.12
Gene ID: 1635
mRNA Refseq: NM_001012732
Protein Refseq: NP_001012750
MIM: 607638
UniProt ID: P32321
Chromosome Location: 4q35.1
Pathway: Metabolic pathways; Pyrimidine metabolism
Function: dCMP deaminase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; metal ion binding; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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