Recombinant Human SET And MYND Domain Containing 2, His-tagged
Cat.No. : | SMYD2-921H |
Product Overview : | Recombinant Human SMYD3 protein (Lys 35 - Ser 369), fused with the GST tag at the N-terminus, was expressed inInsect cells. |
- Specification
- Gene Information
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Cat. No. : | SMYD3-920H |
Description : | SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma ( CRC ) and hepatocellular carcinoma ( HCC ). SMYD3 plays an important role in transcriptional regulation in human carcinogenesis. It activates the transcription of a set of downstream genes. Of these downstream genes, there are several oncogenes and genes associated with cell adhesion (including those of N-Myc, CrkL, Wnt10b, L-selectin, CD31 and galectin-4), which have been shown to have effects on cell viability, adhesion, migration and metastasis. |
Source : | Insect cells. |
Molecular Mass : | The recombinant human SMYD3 / GST chimera consists of 559 amino acids and predicts a molecular mass of 656kDa. It migrates as an approxiamtely 58 KDa band in SDS-PAGE under reducing conditions. |
Predicted N Terminal : | Met. |
Purity : | > 88 % as determined by SDS-PAGE. |
Formulation : | Lyophilized from sterile 20mM Tris,150mM NaCl, 0.5mM DTT, 0.5mM GSH , pH 8.0. |
Endotoxin : | < 1.0 EU per 1μg of the protein as determined by the LAL method. |
Reconstitution : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
Storage And Stability : | Samples are stable for up to twelve months from date of receipt at -700C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | SMYD3 SET and MYND domain containing 3 [ Homo sapiens ] |
Synonyms : | SET and MYND domain containing 3; KMT3E; ZMYND1; ZNFN3A1; FLJ21080; MGC104324; bA74P14.1; SMYD3; bA74P14.1 (novel protein); zinc finger, MYND domain containing 1; zinc finger protein, subfamily 3A (MYND domain containing), 1; EC 2.1.1.43; Zinc finger MYND domain-containing protein 1 |
Gene ID : | 64754 |
mRNA Refseq : | NM_001167740 |
Protein Refseq : | NP_001161212 |
MIM : | 608783 |
UniProt ID : | Q9H7B4 |
Chromosome Location : | 1q44 |
Function : | histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; protein binding; transferase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
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SMYD2-5289R | Recombinant Rat SMYD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Smyd2-5986M | Recombinant Mouse Smyd2 Protein, Myc/DDK-tagged | +Inquiry |
SMYD2-8507M | Recombinant Mouse SMYD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SMYD2-705HCL | Recombinant Human SMYD2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionInvestigations into small molecules and inhibitors targeting SMYD2 are underway, with potential applications in cancer and cardiovascular disease treatment.
Monitoring SMYD2 levels may provide insights into the progression of cardiovascular diseases, aiding in early diagnosis and treatment.
Research suggests that SMYD2 may play a role in neurodegenerative diseases, and exploring its modulation could offer new avenues for therapeutic intervention.
SMYD2 is involved in various cellular processes, including cell cycle regulation, DNA repair, and inflammation, making it a versatile protein with potential implications in multiple diseases.
SMYD2 has been linked to cardiac hypertrophy and heart failure, suggesting its potential as a therapeutic target in the context of cardiovascular diseases.
Customer Reviews (3)
Write a reviewIts compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating SMYD2 protein function and molecular interactions.
The versatility of the SMYD2 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.
the SMYD2 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.
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