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Recombinant Human NR1H4, His-tagged

Cat. No.: NR1H4-3066H
Product Overview: Recombinant Human NR1H4 is expressed inE.Coliwith a His tag at N-terminus. Molecular Weight: 27KDa.
Description: The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that in humans is encoded by the NR1H4 gene.
Source: E.Coli.
Reagents Supplied: 1x dilution buffer A: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1mM DTT.
Quality Control: The purified recombinant protein is greater than 95% homogeneous based on SDS-PAGE analysis.
Activity: 1 unit equals 1 nanogram purified protein. 20 units are sufficient for a gel-mobility shift assay and 100 units are sufficient for a protein-protein interaction assay.
Application: FXR can be used for DNA and protein-protein interactions assays.
Storage Conditions: Store at -80°C.
Gene Name: NR1H4 nuclear receptor subfamily 1, group H, member 4 [ Homo sapiens ]
Synonyms: NR1H4; nuclear receptor subfamily 1, group H, member 4; BAR; FXR; HRR1; HRR-1; RIP14; MGC163445; farnesoid X receptor; Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14; farnesoid X receptor
Gene ID: 9971
mRNA Refseq: NM_005123
Protein Refseq: NP_005114
MIM: 603826
UniProt ID: Q96RI1
Chromosome Location: 12q23.1
Function: bile acid binding; double-stranded DNA binding; metal ion binding; peptide binding; protein N-terminus binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding

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