"SPOP" Related Products

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Recombinant Human Speckle-type POZ Protein, T7-tagged

Cat. No.: SPOP-2992H
Product Overview: Recombinant Human SPOP protein, fused with a T7-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques, 42132Da (374aa).
Description: Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Sequences of amino acids: MSRVPSPPPP AEMSSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE VIKSSTFSSG ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA KFKFSILNAK GEETKAMESQ RAYRFVQGKD WGFKKFIRRD FLLDEANGLL PDDKLTLFCE VSVVQDSVNI SGQNTMNMVK VPECRLADEL GGLWENSRFT DCCLCVAGQE FQAHKAILAA RSPVFSAMFE HEMEESKKNR VEINDVEPEV FKEMMCFIYT GKAPNLDKMA DDLLAAADKY ALERLKVMCE DALCSNLSVE NAAEILILAD LHSADQLKTQ AVDFINYHAS DVLETSGWKS MVVSHPHLVA EAYRSLASAQ CPFLGPPPKR LKQS
Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3
Purity: 95% by SDS - PAGE
Applications: MS. SDS
Gene Name: SPOP speckle-type POZ protein [Homo sapiens]
Synonyms: SPOP; TEF2; speckle-type POZ protein; Roadkill homolog 1; HIB homolog 1; OTTHUMP00000220321; OTTHUMP00000220322; OTTHUMP00000220351; OTTHUMP00000220425; OTTHUMP00000220426; OTTHUMP00000220430; OTTHUMP00000220431
Gene ID: 8405
mRNA Refseq: NM_001007226
Protein Refseq: NP_001007227
MIM: 602650
UniProt ID: O43791
Chromosome Location: 17q21.33
Function: Protein binding

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