Recombinant Human ADP-RibosylationFactorInteracting Protein 2, T7-tagged

• Cat.No.: ARFIP2-3036H
• Product Overview: Recombinant HumanARFIP2 protein was expressed inE.coliwith T7-tag at the N-terminus. The molecular weight is 37856Da.

Specification

• Species: Human
• Source: E.coli
• Tag: T7
• Description: ARFIP2 is a protein that in humans is encoded by the ARFIP2 gene.ARFIP2 is a ubiquitously expressed protein implicated in mediating cross talk between RAC and ARF small GTPases. It has been shown that ARFIP2 binds specifically to GTP-bound ARF1 and ARF6, but binds to Rac-GTP and Rac-GDP with similar affinities. The X-ray structure of arfaptin reveals an elongated, crescent-shaped dimer of 3-helix coiled-coils. Structures of arfaptin with Rac bound to either GDP or the slowly hydrolysable analog GMPPNP show that the switch regions adopt similar conformations in both complexes.
• Sequences of amino acids: 1-341 aa
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
• Purity: 95%

Gene Information

• Gene Name: ARFIP2 ADP-ribosylation factor interacting protein 2 [ Homo sapiens ]
• Synonyms: POR1;arfaptin-2; arfaptin 2; partner of RAC1 (arfaptin 2); ADP-ribosylation factor-interacting protein 2
• Gene ID: 23647
• mRNA Refseq: NM_012402
• Protein Refseq: NP_036534
• MIM: 601638
• UniProt ID: P53365
• Chromosome Location: 11p15
• Function: GTP binding; GTP-dependent protein binding; GTP-dependent protein binding; Rac GTPase binding; protein binding