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Recombinant Human Pyridoxamine 5 -phosphate Oxidase, His-tagged

Cat. No.: PNPO-2868H
Product Overview: Recombinant human PNPO protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. MW = 25.9 kDa (226aa) confirmed by MALDI-TOF (molecular size on SDS-PAGE will appear higher).
Description: PNPO, also known as pyridoxine-5"-phosphate oxidase, is the rate-limiting enzyme in vitamin B6 synthesis. Vitamin B6, or pyridoxal 5-prime-phosphate (PLP), is critical for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts.
Source: E.coli.
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MDPVKQFAAW FEEAVQCPDI GEANAMCLAT CTRDGKPSAR MLLLKGFGKD GFRFFTNFES RKGKELDSNP FASLVFYWEP LNRQVRVEGP VKKLPEEEAE CYFHSRPKSS QIGAVVSHQS SVIPDREYLR KKNEELEQLY QDQEVPKPKS WGGYVLYPQV MEFWQGQTNR LHDRIVFRRG LPTGDSPLGP MTHRGEEDWL YERLAP
Purity: > 90% by SDS – PAGE.
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl, 0.1mM PMSF.
Concentration: 0.5 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PNPO pyridoxamine 5"-phosphate oxidase [ Homo sapiens ]
Synonyms: PNPO; pyridoxamine 5"-phosphate oxidase; PDXPO; FLJ10535; pyridoxine-5"-phosphate oxidase; pyridoxamine-phosphate oxidase; pyridoxal 5"-phosphate synthase; pyridoxine 5"-phosphate oxidase; EC 1.4.3.5
Gene ID: 55163
mRNA Refseq: NM_018129
Protein Refseq: NP_060599
MIM: 603287
UniProt ID: Q9NVS9
Chromosome Location: 17q21.32
Pathway: Metabolic pathways; Vitamin B6 metabolism
Function: FMN binding; oxidoreductase activity, acting on the CH-NH2 group of donors; pyridoxamine-phosphate oxidase activity

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