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Recombinant Human Purine Nucleoside Phosphorylase, His-tagged

Cat. No.: PNP-2872H
Product Overview: Recombinant human PNP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description: PNP belongs to the PNP/MTAP phosphorylase family of proteins. This protein catalyzes the reversible phosphorolysis of ribonucleosides and 2’-deoxyribonucleosides with specificity for guanine, hypoxanthine and their analogs. PNP deficiency is a rare autosomal recessive genetic disease associated with a severe defect in T-lymphocyte function and neurologic disorder in children, comprising four percent of combined immunodeficiency cases.
Source: E.coli.
Sequence: MGSSHHHHHH SSGLVPRGSH MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY GEIPNFPRST VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP NDERFGDRFP AMSDAYDRTM RQRALSTWKQ MGEQRELQEG TYVMVAGPSF ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS.
Purity: > 90% by SDS – PAGE.
MW: 34.2 kDa (309aa) confirmed by MALDI-TOF.
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT, 50mM NaCl, 0.1mM PMSF.
Concentration: 1mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PNP purine nucleoside phosphorylase [ Homo sapiens ]
Synonyms: PNP; purine nucleoside phosphorylase; FLJ94043, FLJ97288, FLJ97312, MGC117396, MGC125915, MGC125916, NP, PRO1837, PUNP; inosine phosphorylase; purine-nucleoside:orthophosphate ribosyltransferase
Gene ID: 4860
mRNA Refseq: NM_000270
Protein Refseq: NP_000261
MIM: 164050
UniProt ID: P00491
Chromosome Location: 14q13.1
Pathway: Metabolic pathways; Nicotinate and nicotinamide metabolism; Metabolism of nucleotides
Function: drug binding; nucleoside binding; purine-nucleoside phosphorylase activity

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