|Product Overview:||Recombinant HumanGIPC1 (1-333 aa) is expressed in E.Coli with a T7 tag at N-terminus.|
|Description:||GIPC1 is a PDZ domain containing protein that interacts with RGS-GAIP and the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating Clathrin-coated vesicular trafficking. GIPC also associates with membrane bound Semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain.|
|Formulation:||10 mM Tris. pH 8.0. 0.1% Triton X-100.0.002% NaN3. 10mM DTT.|
|Function:||PDZ domain binding; actin binding; myosin binding; protein binding; protein homodimerization activity; receptor binding|
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