"PIN1" Related Products


Recombinant Human PIN1, T7-tagged

Cat. No. : PIN1-2901H
Product Overview : Recombinant HumanPIN1 (1-163 aa) is expressed in E.Coli with a T7 tag at N-terminus.
Description : Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.
Source : E.Coli.
MW : 18243 Da.
Purity : 90%.
Formulation : 10 mM Tris. pH 8.0. 0.1% Triton X-100.0.002% NaN3.
Application : MS. SDS.
Gene ID : 5300
mRNA Refseq : NM_000143
Protein Refseq : NP_000134
MIM : 136850
UniProt ID : P07954
Chromosome Location : 1q42.1
Function : fumarate hydratase activity, fumarate hydratase activity, lyase activity

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