Recombinant Human PIN1, T7-tagged

• Cat.No.: PIN1-2901H
• Product Overview: Recombinant HumanPIN1 (1-163 aa) is expressed in E.Coli with a T7 tag at N-terminus.

Specification

• Cat. No.: PIN1-2901H
• Description: Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.
• Source: E.Coli.
• MW: 18243 Da.
• Purity: 90%.
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100.0.002% NaN3.
• Application: MS. SDS.

Gene Information

• Gene ID: 5300
• mRNA Refseq: NM_000143
• Protein Refseq: NP_000134
• MIM: 136850
• UniProt ID: P07954
• Chromosome Location: 1q42.1
• Function: fumarate hydratase activity, fumarate hydratase activity, lyase activity