"TCL1A" Related Products


Recombinant Human TCL1A, T7-tagged

Cat. No. : TCL1A-2903H
Product Overview : Recombinant Human TCL1A (1-114 aa) is expressed in E.Coli with a T7 tag at N-terminus.
Description : TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism.
Source : E.Coli.
MW : 13460 Da.
Purity : 95%.
Formulation : 10 mM Tris. pH 8.0. 0.1% Triton X-100.0.002% NaN3. 10mM DTT.
Application : MS. SDS.
Synonyms : TCL1A; T-cell leukemia/lymphoma 1A; TCL1; T-cell lymphoma-1; T-cell lymphoma-1A; TCL-1; Oncogene TCL1; Protein p14 TCL1
Gene ID : 8115
mRNA Refseq : NM_001098725
Protein Refseq : NP_001092195
MIM : 186960
UniProt ID : P56279
Chromosome Location : 14q32.1
Function : protein binding

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