Recombinant Human TCL1A, T7-tagged

• Cat.No.: TCL1A-2903H
• Product Overview: Recombinant Human TCL1A (1-114 aa) is expressed in E.Coli with a T7 tag at N-terminus.

Specification

• Cat. No.: TCL1A-2903H
• Description: TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism.
• Source: E.Coli.
• MW: 13460 Da.
• Purity: 95%.
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100.0.002% NaN3. 10mM DTT.
• Application: MS. SDS.

Gene Information

• Synonyms: TCL1A; T-cell leukemia/lymphoma 1A; TCL1; T-cell lymphoma-1; T-cell lymphoma-1A; TCL-1; Oncogene TCL1; Protein p14 TCL1
• Gene ID: 8115
• mRNA Refseq: NM_001098725
• Protein Refseq: NP_001092195
• MIM: 186960
• UniProt ID: P56279
• Chromosome Location: 14q32.1
• Function: protein binding