"SRPK1" Related Products

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Recombinant Human SFRS Protein Kinase 1, GST-His

Cat. No.: SRPK1-713H
Product Overview: Recombinant Human SRPK1, Amino acids M1-S655, N-terminally fused to GST-HIS6-Thrombin cleavage site, was expressed inSf9cells. MW = 104,220 Da.
Description: SRPK1 is a Ser/Thr protein kinase that has sequence and function similar to SRPK2. In human cancer cells, it was observed that inactivation of SRPK1 induces cellular resistance to anticancer drugs such as cisplatin and bleomycin. SRPK1 phosphorylates serine/arginine-rich (SR) proteins, such as splicing factors ASF/SF2, SC35, and SRp55, in their arginine/serine-rich (RS) domains in vitro.
Source: Baculovirus infected Sf9 cells.
Purification: One-step affinity purification using GSH-agarose.
Product Identity: SRPK1 was confirmed as human SRPK1 by mass spectroscopy LC-ESI-MS/MS (Protagen AG, Germany).
Storage Buffer: 50 mM Tris-HCl, pH 8.0; 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
Concentration: 0.250 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity: 91 pmol/μg×min.
Storage: -80°C. Avoid repeated freeze-thaw cycles!
Gene Name: SRPK1 SFRS protein kinase 1 [ Homo sapiens ]
Synonyms: SRPK1; SFRS protein kinase 1; SFRSK1; SR protein kinase 1; EC 2.7.11.1; SR-protein-specific kinase 1; Serine/arginine-rich protein-specific kinase 1; Serine/threonine-protein kinase SRPK1
Gene ID: 6732
mRNA Refseq: NM_003137
Protein Refseq: NP_003128
MIM: 601939
UniProt ID: Q96SB4
Chromosome Location: 6p21.3-p21.2
Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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