"PAK3" Related Products

Recombinant Human PAK3, GST-His

Cat. No.: PAK3-722H
Product Overview: RecombinantHuman PAK3, full length, amino acids M1-R544, N-terminally fused to GST-HIS6-Thrombin cleavage site, was expressed inSf9insect cells. MW = 90,588 Da.
Description: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets.
Source: Baculovirus infected Sf9 cells.
Purification: One-step affinity purification using GSH-agarose.
Product Identity: PAK3 was confirmed as PAK3 by by mass spectroscopy LC-ESI-MS/MS (Protagen AG,Germany).
Storage Buffer: 50 mM HEPES-NaOH, pH 7.5; 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
Concentration: 0.360 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity: 79 pmol/μg×min.
Storage: -80°C. Avoid repeated freeze-thaw cycles!
Gene Name: PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 [ Homo sapiens ]
Synonyms: PAK3; p21 protein (Cdc42/Rac)-activated kinase 3; bPAK; MRX30; MRX47; OPHN3; hPAK3; CDKN1A; PAK3beta; p21-activated kinase 3; beta-PAK; oligophrenin-3; OTTHUMP00000023856; p21 (CDKN1A)-activated kinase 3; serine/threonine-protein kinase PAK 3; EC
Gene ID: 5063
mRNA Refseq: NM_001128166
Protein Refseq: NP_001121638
MIM: 300142
UniProt ID: O75914
Chromosome Location: Xq23
Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway; Axon guidance
Function: ATP binding; collagen binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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