Recombinant Human PAK4, GST-His

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Recombinant Human PAK4, GST-His

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Cat. No. : PAK4-723H
Product Overview : Recombinant Human PAK4, full length, amino acids M1-R591, N-terminally fused to GST-HIS6-Thrombin cleavage site, was expressed inSf9insect cells. MW = 93,968 Da.
Description : PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases.
Source : Baculovirus infected Sf9 cells.
Purification : One-step affinity purification using GSH-agarose.
Product Identity : PAK4 was confirmed as PAK4 by by mass spectroscopy LC-ESI-MS/MS (Protagen AG, Germany)
Storage Buffer : 50 mM Tris-HCl, pH 8.0; 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
Concentration : 0.154 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity : 3 pmol/μg×min.
Storage : -80°C. Avoid repeated freeze-thaw cycles!
PDB rendering based on 2bva. :

Gene Name : PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Homo sapiens ]
Synonyms : PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; Serine/threonine-protein kinase PAK 4; KIAA1142; EC 2.7.11.1; PAK-4
Gene ID : 10298
mRNA Refseq : NM_001014831
Protein Refseq : NP_001014831
MIM : 605451
UniProt ID : O96013
Chromosome Location : 19q13.2
Pathway : Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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