"NEK2" Related Products


Recombinant Human NEK2, Active

Cat. No.: NEK2-663H
Description: SGK2 is a member of the serum- and glucocorticoid-induced kinases (SGK) which are serine-threonine kinases and belong to the "AGC" kinase subfamily, which includes protein kinases A, G, and C, and its catalytic domain is most similar to protein kinase B (PKB). SGK2, like the other two isoforms SGK1 and SGK3, is stimulated by insulin and insulin-like growth factor-1 (IGF-1), and has been shown to enhance Na(+)/K(+)-ATPase activity in a variety of cells.
Source: E.coli.
Application: Kinase activity is measured as the molar amount of phosphate incorporated into myelin basic protein, per minute per mg protein at 30 °C using a final concentration of 50 μM [32P] ATP.
Biochem/physiol Actions: Nek2 (nimA-related kinase 2) is a cell cycle-regulated protein kinase with maximal activity at the onset of mitosis that localizes to the centrosome.
Physical Form: Solution in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, and 30% glycerol.
Assay: ≥85% (SDS-PAGE).
Form: buffered aqueous glycerol solution.
Mol Wt: protein apparent mol wt ~80 kDa.
Storage Temp: −70°C.
Gene Name: NEK2 NIMA (never in mitosis gene a)-related kinase 2 [ Homo sapiens ]
Synonyms: NEK2; NIMA (never in mitosis gene a)-related kinase 2; NLK1; NEK2A; HsPK21; NIMA-related kinase 2; EC; serine/threonine-protein kinase Nek2; nimA-like protein kinase 1; nimA-related protein kinase 2; never in mitosis A-related kinase 2
Gene ID: 4751
mRNA Refseq: NM_002497
Protein Refseq: NP_002488
MIM: 604043
UniProt ID: P51955
Chromosome Location: 1q32.2-q41
Pathway: Cell Cycle, Mitotic
Function: ATP binding; magnesium ion binding; transferase activity; nucleotide binding; protein phosphatase binding; protein serine/threonine kinase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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