Recombinant Human NEK2, Active NEK2-663H

Recombinant Human NEK2, Active


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Recombinant Human NEK2, Active

NEK2 Related Products

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Cat. No. : NEK2-663H
Description : SGK2 is a member of the serum- and glucocorticoid-induced kinases (SGK) which are serine-threonine kinases and belong to the "AGC" kinase subfamily, which includes protein kinases A, G, and C, and its catalytic domain is most similar to protein kinase B (PKB). SGK2, like the other two isoforms SGK1 and SGK3, is stimulated by insulin and insulin-like growth factor-1 (IGF-1), and has been shown to enhance Na(+)/K(+)-ATPase activity in a variety of cells.
Source : E.coli.
Application : Kinase activity is measured as the molar amount of phosphate incorporated into myelin basic protein, per minute per mg protein at 30 °C using a final concentration of 50 μM [32P] ATP.
Biochem/physiol Actions : Nek2 (nimA-related kinase 2) is a cell cycle-regulated protein kinase with maximal activity at the onset of mitosis that localizes to the centrosome.
Physical Form : Solution in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, and 30% glycerol.
Assay : ≥85% (SDS-PAGE).
Form : buffered aqueous glycerol solution.
Mol Wt : protein apparent mol wt ~80 kDa.
Storage Temp : −70°C.
PDB rendering based on 2jav. :

Gene Name : NEK2 NIMA (never in mitosis gene a)-related kinase 2 [ Homo sapiens ]
Synonyms : NEK2; NIMA (never in mitosis gene a)-related kinase 2; NLK1; NEK2A; HsPK21; NIMA-related kinase 2; EC; serine/threonine-protein kinase Nek2; nimA-like protein kinase 1; nimA-related protein kinase 2; never in mitosis A-related kinase 2
Gene ID : 4751
mRNA Refseq : NM_002497
Protein Refseq : NP_002488
MIM : 604043
UniProt ID : P51955
Chromosome Location : 1q32.2-q41
Pathway : Cell Cycle, Mitotic
Function : ATP binding; magnesium ion binding; transferase activity; nucleotide binding; protein phosphatase binding; protein serine/threonine kinase activity

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