Guanosine monophosphate reductase 2

• Cat.No.: CBCRY17

Specification

• Source: E.coli
• Tag: Non
• Background: Guanosine monophosphate reductase (GMPR) Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
• Protein Classification: Oxidoreductase
• Structure Weight: 161477.73 Da
• Polymer: 1
• Molecule: GMP reductase 2
• Chain Length: 366 amino acids
• PDB ID: 2A7R
• MMDB ID: 37032
• Method: X-Ray Diffraction
• Resolution: 3.0 Å
• Ligand Chemical Component: guanosine-5’-monophosphate; sulfate ion
• Reference: Li, J., Wei, Z., Zheng, M., Gu, X., Deng, Y., Qiu, R., Chen, F., Ji, C., Gong, W., Xie, Y., Mao, Y.(2006) Crystal Structure of Human Guanosine Monophosphate Reductase 2 (GMPR2) in Complex with GMPJ.Mol.Biol.355: 980-988

Gene Information

• Gene Name: GMPR2
• Synonyms: MGC15084; MGC830; GMP reductase 2; guanosine 5"-monophosphate oxidoreductase 2; guanosine monophosphate reductase isolog; EC 1.7.1.7
• UniProt ID: Q9P2T1
• Gene ID: 51292
• Chromosome Location: 14q12
• Function: GMP reductase activity; metal ion binding; oxidoreductase activity; potassium ion binding