Human CHMP2B Knockdown Cell Lysate

• Cat.No.: CHMP2B-110HKCL
• Product Overview: WB-validated CHMP2B Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 24 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg CHMP2B KD HeLa cell lysate
• Protein Pathways: Endocytosis
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: CHMP2B charged multivesicular body protein 2B [ Homo sapiens (human) ]
• Official Symbol: CHMP2B
• Synonyms: CHMP2B; charged multivesicular body protein 2B; chromatin modifying protein 2B; charged multivesicular body protein 2b; CHMP2.5; DKFZP564O123; VPS2 homolog B (S. cerevisiae); VPS2B; VPS2 homolog B; vacuolar protein-sorting-associated protein 2-2; DMT1; VPS2-2; DKFZp564O123
• Gene ID: 25978
• mRNA Refseq: NM_001244644
• Protein Refseq: NP_001231573
• MIM: 609512
• UniProt ID: Q9UQN3