Human FDPS Knockdown Cell Lysate

• Cat.No.: FDPS-164HKCL
• Product Overview: WB-validated FDPS Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 48 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg FDPS KD HeLa cell lysate
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Terpenoid backbone biosynthesis
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: FDPS farnesyl diphosphate synthase [ Homo sapiens (human) ]
• Official Symbol: FDPS
• Synonyms: FDPS; farnesyl diphosphate synthase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; dimethylallyltranstransferase; geranyltranstransferase; FPP synthase; FPP synthetase; (2E,6E)-farnesyl diphosphate synthase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPS; FPPS
• Gene ID: 2224
• mRNA Refseq: NM_001135821
• Protein Refseq: NP_001129293
• MIM: 134629
• UniProt ID: P14324