Human GEMIN2 Knockdown Cell Lysate

• Cat.No.: GEMIN2-174HKCL
• Product Overview: WB-validated GEMIN2 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 32 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg GEMIN2 KD HeLa cell lysate
• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: GEMIN2 gem (nuclear organelle) associated protein 2 [ Homo sapiens (human) ]
• Official Symbol: GEMIN2
• Synonyms: GEMIN2; gem (nuclear organelle) associated protein 2; SIP1, survival of motor neuron protein interacting protein 1; gem-associated protein 2; gemin-2; component of gems 2; SMN interacting protein 1-delta; survival of motor neuron protein interacting protein 1; SIP1; SIP1-delta
• Gene ID: 8487
• mRNA Refseq: NM_001009182
• Protein Refseq: NP_001009182
• MIM: 602595
• UniProt ID: O14893