Human MMUT Knockdown Cell Lysate

• Cat.No.: MMUT-372HKCL
• Product Overview: WB-validated MMUT Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 83 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg MMUT KD HeLa cell lysate
• Protein Families: Druggable Genome
• Protein Pathways: leucine and isoleucine degradation, Metabolic pathways, Propanoate metabolism, Valine
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: MMUT methylmalonyl-CoA mutase [ Homo sapiens (human) ]
• Official Symbol: MMUT
• Synonyms: MMUT; methylmalonyl-CoA mutase; MCM; MUT; methylmalonyl-CoA mutase, mitochondrial; methylmalonyl Coenzyme A mutase; methylmalonyl-CoA isomerase; methylmalonyl-CoA mutase c.*192delA; methylmalonyl-CoA mutase c.*51C>G; methylmalonyl-CoA mutase variant c.1495G>A; methylmalonyl-CoA mutase variant c.2011A>G; methylmalonyl-CoA mutase variant c.2150G>T; methylmalonyl-CoA mutase variant c.322C>T; methylmalonyl-CoA mutase variant c.613_615delGAA; methylmalonyl-CoA mutase variant c.636G>A; methylmalonyl-CoA mutase variant c.643G>A; mutant methylmalonyl CoA mutase; EC 5.4.99.2
• Gene ID: 4594
• mRNA Refseq: NM_000255
• Protein Refseq: NP_000246
• MIM: 609058
• UniProt ID: P22033