Mouse Anti-Human CD33C Molecule Monoclonal Antibody
Cat.No. : | CAB11498MH |
Product Overview : | Mouse monoclonal antibody to human CD33C molecule. |
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Antigen Description : | CMRF35-like molecule 6, also known as CD300 antigen-like family member C, Immunoglobulin superfamily member 16, CMRF35-A1, CD300C and CMRF35, is a single-pass type I membrane protein which belongs to the CD300 family. CD300c / CMRF-35 contains one Ig-like V-type (immunoglobulin-like) domain. CD300c / CMRF-35 is present on the surface of monocytes, neutrophils, a proportion of peripheral blood T-lymphocytes and B-lymphocytes and lymphocytic cell lines. The CD300c (CMRF-35A) and CD300a (CMRF-35H) molecules are leukocyte surface proteins that are part of a larger family of immunoregulatory molecules encoded by a gene complex on human chromosome 17. The CD300a protein contains four ITIMs and is highly homologous to CD300c. CD300a/c RNA and surface expression were downregulated after stimulation of plasmacytoid dendritic cells (pDCs) with TLR7 and TLR9 ligands. Exogenous interferon (IFN)-alpha down-regulated CD300a/c expression, whereas neutralizing IFN-alpha abolished TLR ligand-induced CD300a/c down-regulation. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300a and CD300c are indistinguishable on the surface of NK cells. |
Specificity : | Human CD300C. No cross-reactivity with human cell lysate ( 293 cell line ) in ELISA. |
Immunogen : | Recombinant Human CD300C Protein |
Host : | Mouse |
Isotype : | Mouse IgG1 |
Species : | Human |
Clone : | 2B7G9 |
Purification : | Protein A affinity chromatography |
Applications : | Western Blot; ELISA |
Dilution : | Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect Human CD300C in WB. Using a DAB detection system, the detection limit for Human CD300C is approximately 20 ng/lane under reducing conditions. Use of this antibody under non-reducing conditions is not recommended.Direct ELISA: This antibody can be used at 0.5 - 1 μg with the appropriate secondary reagents to detect Human CD300C. The detection limit for Human CD300C is approximately 0.16 ng/well. |
Preparation : | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant Human CD300C. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Format : | 0.2 μm filtered solution in PBS with 5% trehalose |
Storage : | This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Tag : | Non |
Gene Name : | CD300C CD300c molecule [ Homo sapiens ] |
Official Symbol : | CD300C |
Synonyms : | CD300C; CD300c molecule; CD300c antigen; CMRF35-like molecule 6; CMRF 35A; CMRF35; CMRF35A; IGSF16; LIR; CMRF35 antigen; CD300 antigen-like family member C; immunoglobulin superfamily member 16; CMRF35 leukocyte immunoglobulin-like receptor; CMRF35A leukocyte immunoglobulin-like receptor; CLM-6; CMRF-35; CMRF-35A; CMRF35A1; CMRF35-A1; |
Gene ID : | 10871 |
mRNA Refseq : | NM_006678 |
Protein Refseq : | NP_006669 |
MIM : | 606786 |
UniProt ID : | Q08708 |
Chromosome Location : | 17q25.2 |
Function : | receptor activity; transmembrane signaling receptor activity; |
Products Types
◆ Recombinant Protein | ||
CD300C-1451M | Recombinant Mouse CD300C Protein, His (Fc)-Avi-tagged | +Inquiry |
CD300C-3087M | Active Recombinant mouse CD300C Protein, mIgG2A-tagged | +Inquiry |
CD300C-148H | Recombinant Human CD300C Protein, His-tagged | +Inquiry |
CD300C-0779H | Recombinant Human CD300C Protein, GST-Tagged | +Inquiry |
Cd300c-4533M | Recombinant Mouse Cd300c protein, GST-tagged | +Inquiry |
◆ Lysates | ||
CD300C-2096HCL | Recombinant Human CD300C cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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