|Product Overview:||This product is the Fluorescein labeled Agaricus bisporus lectin and has sugar specificity against Gal(b-1,4)GalNAc (T disaccharide). The excitation maximum is at 495 nm and the emission maximum is at 515 nm.|
|Description:||Agaricus bisporus lectin (ABL) isolated from the edible white button mushroom, is composed of two to four very similar isolectins, each a tetramer of approximately 17 kD subunits. This lectin binds the Thomsen-Friedenreich antigen, also called T disaccharide, galactosyl (β-1,3) N-acetylgalactosamine. Unlike peanut agglutinin, which does not bind sialylated T antigen, ABL binds either sialylated or asialylated forms. Also, whereas peanut agglutinin has a proliferative effect on cancer cells, ABL is anti-proliferative, apparently without cytotoxicity. ABL binds all blood groups and O-linked glycans of IgA subclasses. Simple mono- and disaccharides are only marginally inhibitory.|
|Form:||10 mM HEPES, pH 7.5, 150 mM NaCl, 0.08% sodium azide|
|Bio-activity:||Sugar Specificity: Gal(b-1,3)GalNAc (T disaccharide)|
|Storage:||Refrigerate in the dark.|
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