| Species : |
Bovine |
| Source : |
Testes |
| Description : |
Calmodulin is a bioactive protein isolated from bovine testes. The material is derived fromindividually marked animals born and raised in Sweden, a country where BSE has not beena problem. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells.By binding to and regulating various protein targets, it affects cellular processes such asmetabolism, nerve growth, apoptosis, inflammation, muscle contra ction and memory.
Calmodulin is used by many proteins as a calcium sensor and signal transducer, as theproteins themselves are not able to bind calcium. The molecule can bind a maximum offour calcium ions and by undergoing post-translational modificat ions such as acetylation,phosphorylation, proteolytic cleavage and methylation, its functions can potentially be altered. |
| Form : |
Lyophilized white powder or flocculate |
| Applications : |
1. Protein calcium-binding studies on the regulation of a multitud e of different protein targets
2. Activation of cyclic nucleotide-dependent phosphodiesterase
3. Co-factor/activator for kinase studies
4. Studies of edema factor toxin and anthrax bacteria |
| Notes : |
For laboratory use only. |
| Storage : |
Stable for at least 5 years from production date when stored at -20 centigrade. May be shipped atambient temperature. After recon-stitution in PBS pH 7.4, the solution may be stored frozen inworking aliquots for up to 12 months. Repeated freezing and thawing is not recommended. Ifslight turbidity centigradecurs upon prolonged storage, clarify the solution by centrifugation before use. |
| Storage Buffer : |
50 mM NH4HCO3 with10 μM CaCl2. No preservatives are added. |
