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Native Human C3c Protein

Cat.No. : C3c-11H
Product Overview : C3c is derived from iC3b (inactivated C3b) by proteolytic cleavage.
Extinction Coefficient: A280 nm = 1.10 at 1.0 mg/mL
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Description : iC3b is created by cleavage of C3b by factor I in the presence of factor H, CR1 or MCP. C3c can be produced by an additional cleavage by factor I if the iC3b is bound to CR1. Factor H cannot serve as a cofactor for this cleavage. C3c can also be produced by the action of trypsin-like proteases on iC3b. If the C3b precursor was attached to a surface, then the iC3b will remain attached to that surface and when iC3b is cleaved the C3c is released into the surrounding solution while the C3dg/C3d fragment remains on that surface. The breakdown of fluid phase C3b is similar, but in this case both C3c and C3dg/C3d are soluble fragments.
Source : Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II).
Species : Human
Form : Frozen liquid
Molecular Mass : 139 kDa (3 chains)
Purity : > 90% by SDS-PAGE
Storage : At -70 centigrade or below. Avoid freeze/thaw.
Concentration : 1 mg/mL
Storage Buffer : 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2
Preservative : None, 0.22 μm filtered.
Official Symbol : C3c
Synonyms : acylation-stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3; c3 complement; C3a anaphylatoxin; C3a; C3b; CO3; Complement C3; Complement C3c alpha' chain fragment 2; Complement C3c; Complement component 3; Complement component C3; Complement component C3a; Complement component C3b; Complement factor 3; CPAMD1; Prepro C3
Official Symbol : C3c
Synonyms : acylation-stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3; c3 complement; C3a anaphylatoxin; C3a; C3b; CO3; Complement C3; Complement C3c alpha' chain fragment 2; Complement C3c; Complement component 3; Complement component C3; Complement component C3a; Complement component C3b; Complement factor 3; CPAMD1; Prepro C3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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