Native Human Immunoglobulin G4 (IgG4)

• Cat.No.: IgG4-232H

Specification

• Description: IgG4 antibodies will dominate the IgG response in schistosomiasis, lymphatic filariasis, and in patients after allergen immunotherapy. Unlike the other IgG subclasses, IgG4 does not activate complement. A combined IgA-IgG4 deficiency has been associated with recurrent pyogenic infections.
• Source: Human Plasma
• Species: Human
• Form: Frozen
• Molecular Mass: MW: 146,000
• Purity: >=95% by SDS-PAGE.
• Usage: For research use only.
• Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Stability: >1 year
• Storage: <=>
• Storage Buffer: 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.
• Publication:
  Observation of Heavy-Chain C-Terminal Amidation in Human Endogenous IgG (2022)
  Observation of Heavy-Chain C-Terminal Des-GK Truncation in Recombinant and Human Endogenous IgG4 (2023)