Recombinan Human EGLN1 protein, FLAG-tagged

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Recombinan Human EGLN1 protein, FLAG-tagged

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Cat.No. : EGLN1-001H
Product Overview : Recombinant human PHD2 (EGLN1) protein was expressed in a baculovirus expression system as the full length protein (accession number NP_071334.1) with an N-terminal FLAG tag.
Description : The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
Source : Insect cells
Species : Human
Tag : FLAG
Molecular Mass : 47 kDa
Applications : This protein is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
Storage : Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Storage Buffer : Recombinant PHD2 / EGLN1 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5 mM TCEP.
10% SDS-PAGE Coomassie staining :

MALDI-TOF for PHD2 / EGLN1 protein :

3 µM HIF1A peptide was incubated with 300 nM PHD2 protein in 30 µl reaction system for 2 hours at 30 centigrade. The reaction product was detected by MALDI-TOF. Single 3 µM HIF1-α peptide was used as negative control.

Gene Name : EGLN1 egl-9 family hypoxia inducible factor 1 [ Homo sapiens (human) ]
Official Symbol : EGLN1
Synonyms : EGLN1; egl-9 family hypoxia inducible factor 1; HPH2; PHD2; SM20; ECYT3; HALAH; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2; egl nine homolog 1; HIF-prolyl hydroxylase 2; egl nine-like protein 1; hypoxia-inducible factor prolyl hydroxylase 2; prolyl hydroxylase domain-containing protein 2; zinc finger MYND domain-containing protein 6; EC 1.14.11.29
Gene ID : 54583
mRNA Refseq : NM_022051
Protein Refseq : NP_071334
MIM : 606425
UniProt ID : Q9GZT9

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