- 2019-nCoV(37)
- BCoV(2)
- Coronavirus(1)
- COVID-19(110)
- HCoV-229E(1)
- HCoV-EMC/2012(2)
- HCoV-HKU1(1)
- HCoV-NL63(1)
- HCoV-OC43(3)
- Human(1)
- Human coronavirus OC43(1)
- MERS-CoV(2)
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- SARS-CoV-2(10)
Recombinant 2019-nCoV S(HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) Protein, His-tagged
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| Cat.No. : | Spike-048V |
| Product Overview : | Recombinant 2019-nCoV S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H), His Tag (SPN-C52H6) is the ectodomain of SARS-CoV-2 S protein that contains AA Val 16 - Pro 1213 (Accession # QHD43416.1) and HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H mutations, which have become increasingly common in SARS-CoV-2 viruses from around the world. The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. |
| Description : | It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. |
| Source : | HEK293 |
| Species : | 2019-nCoV |
| Tag : | His |
| Form : | PBS |
| Molecular Mass : | The protein has a calculated MW of 137.8 kDa. |
| Protein length : | Val 16 - Pro 1213 |
| Storage : | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
| Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
| Gene Name : | S surface glycoprotein [ Severe acute respiratory syndrome coronavirus 2 ] |
| Official Symbol : | S |
| Synonyms : | Spike, S1 protein, Spike glycoprotein Subunit1, S glycoprotein Subunit1, Spike protein S1, COVID-19 |
| Gene ID : | 43740568 |
| Protein Refseq : | YP_009724390.1 |
| UniProt ID : | P0DTC2 |
◆ Recombinant Protein
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| Spike-327V | Recombinant COVID-19 Spike RBD (E406Q) protein, His-tagged | +Inquiry |
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◆ Lysates
| Spike-1058HCL | Recombinant HCoV-EMC/2012 Spike cell lysate | +Inquiry |
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