Recombinant AAV-2 VP3 Protein, Strep/SUMO/His-tagged
Cat.No. : | VP3-04A |
Product Overview : | Recombinant AAV-2 VP3 Protein with Strep/SUMO/His tag was expressed in E. coli. |
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Description : | Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus. |
Source : | E. coli |
Species : | AAV-2 |
Tag : | Strep/SUMO/His |
Molecular Mass : | 75.17 kDa |
AA Sequence : | MNWSHPQFEKSSGSSGGHHHHHHGG SGGSGSDSEVNQEAKPEVKPEVKPE THINLKVSDGSSEIFFKIKKTTPLR RLMEAFAKRQGKEMDSLRFLYDGIR IQADQAPEDLDMEDNDIIEAHREQI GGLNSSSVDMATGSGAPMADNNEGA DGVGNSSGNWHCDSTWMGDRVITTS TRTWALPTYNNHLYKQISSQSGASN DNHYFGYSTPWGYFDFNRFHCHFSP RDWQRLINNNWGFRPKRLNFKLFNI QVKEVTQNDGTTTIANNLTSTVQVF TDSEYQLPYVLGSAHQGCLPPFPAD VFMVPQYGYLTLNNGSQAVGRSSFY CLEYFPSQMLRTGNNFTFSYTFEDV PFHSSYAHSQSLDRLMNPLIDQYLY YLSRTNTPSGTTTQSRLQFSQAGAS DIRDQSRNWLPGPCYRQQRVSKTSA DNNNSEYSWTGATKYHLNGRDSLVN PGPAMASHKDDEEKFFPQSGVLIFG KQGSEKTNVDIEKVMITDEEEIRTT NPVATEQYGSVSTNLQRGNRQAATA DVNTQGVLPGMVWQDRDVYLQGPIW AKIPHTDGHFHPSPLMGGFGLKHPP PQILIKNTPVPANPSTTFSAAKFAS FITQYSTGQVSVEIEWELQKENSKR WNPEIQYTSNYNKSVNVDFTVDTNG VYSEPRPIGTRYLTRNLLE |
Purity : | >85% by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 0.5 mg/mL |
Storage Buffer : | PBS, pH 7.4 |
Gene Name : | AAV2gp07 major coat protein VP3 [ Adeno-associated virus - 2 ] |
Official Symbol : | AAV2gp07 |
Synonyms : | AAV2gp07; major coat protein VP3; major coat protein VP3 |
Gene ID : | 4192016 |
Protein Refseq : | YP_680428 |
UniProt ID : | P03135 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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