Recombinant Active Human EGFR (d746-750 S768I) Mutant Protein, GST-tagged EGFR-22H

Recombinant Active Human EGFR (d746-750 S768I) Mutant Protein, GST-tagged

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Cat.No. : EGFR-22H Optional Service: Optional requirements on this protein
Product Overview : Recombinant human EGFR (d746-750 S768I) (668-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Source : Insect cell
Species : Human
Tag : GST
Molecular Mass : Approx 89~100 kDa
Purity : > 80%
Stability : One year at -70 centigrade from data of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.05 μg/μL
Storage Buffer : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 25% glycerol.
Shipping : Dry ice
Specific Activity :

The specific activity of EGFR (d746-750 S768I) was determined to be 22 nmol/min/mg as per activity assay protocol.

Purity :

The purity of EGFR (d746-750 S768I) was determined to be >80 % by densitometry.

Gene Name : EGFR epidermal growth factor receptor [ Homo sapiens (human) ]
Official Symbol : EGFR
Synonyms : EGFR; epidermal growth factor receptor; ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2; epidermal growth factor receptor; EGFR vIII; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; EC 2.7.10.1
Gene ID : 1956
mRNA Refseq : NM_005228
Protein Refseq : NP_005219
MIM : 131550
UniProt ID : P00533
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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