Recombinant Active Mouse IL36G Protein, His-tagged(C-ter)
|Product Overview :||Recombinant Active Mouse IL36G Protein with His tag (C-ter) was expressed in E. coli.|
- Gene Information
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|Description :||The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]|
|Source :||E. coli|
|Bio-activity :||Determined by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is < 15 ng/mL. The specific activity of recombinant mouse IL-36 gamma is > 6 x 10^4 IU/mg.|
|AA Sequence :||MGRETPDFGEVFDLDQQVWIFRNQA LVTVPRSHRVTPVSVTILPCKYPES LEQDKGIAIYLGIQNPDKCLFCKEV NGHPTLLLKEEKILDLYHHPEPMKP FLFYHTRTGGTSTFESVAFPGHYIA SSKTGNPIFLTSKKGEYYNINFNLD IKS|
|Endotoxin :||Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.|
|Purity :||> 98% (by SDS-PAGE)|
|Notes :||For laboratory research only, not for drug, diagnostic or other use.|
|Storage :||Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.|
|Storage Buffer :||PBS (pH 7.4)|
|Reconstitution :||It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.|
|Gene Name :||Il36g interleukin 36G [ Mus musculus (house mouse) ]|
|Official Symbol :||Il36g|
|Synonyms :||Il36g; interleukin 36G; If36g; Il1f9; IL-36gamma;|
|Gene ID :||215257|
|mRNA Refseq :||NM_153511|
|Protein Refseq :||NP_705731|
|UniProt ID :||Q3U0P4|
|IL36G-5235HCL||Recombinant Human IL1F9 293 Cell Lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
It is currently mainly used in the treatment of skin inflammatory diseases, and the therapeutic potential of other inflammatory diseases needs further study.
It is mainly used in the research of the mechanism of skin inflammation and the development of new drugs.
The production of IL36G usually adopts genetic engineering technology, its genes are introduced into the expression host, and pure is obtained through fermentation, purification and other steps.
IL36G can be targeted to inhibit inflammation by directly acting on inflammation-related signaling pathways, which may be more effective than other drugs.
IL36G activates inflammation-related signaling pathways by binding to its receptors, promoting the activation of immune cells and the release of inflammatory factors.
The side effects of IL36G may include skin irritation, allergic reactions, etc. The specific side effects can vary from individual to individual.
Customer Reviews (3)Write a review
When experimenting with IL36G, the results are very reproducible. -
Production process of IL36G products is environmentally friendly and sustainable, in line with the concept of green production. -
IL36G has good solubility and ion exchange ability, which is convenient for subsequent experimental treatment and purification. -
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