Description : |
Cytokines and hormones belonging to the transforming growth factor beta (TGFβ) superfamily such as the activin, anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal, are involved in a variety of physiological processes including growth, cell differentiation, homeostasis, osteogenesis, and apoptosis. They initiate signaling through heteromeric complexes of a type I and a type I I serine/threonine kinase receptor. The two type receptors are type I transmembrane proteins and are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found in the type I receptors. Type II receptors are required for binding ligands and recruitment of type I receptors which then form stable complexes, and type I receptors are essential for signaling transduction. ALK2, also termed as ACVR1, ActRI, SKR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or IIB. In addition, ALK2 is also identified as a BMP type I receptor. ACVR1 has been demonstrated to form complex with either the BMP-2/7-bound BMPR-II or ACVR2A/ACVR2B and transduce signals to downstream components R-SMADs. Recombinant soluble ALK2 does not bind activin. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
Source : |
Human Cells |
Species : |
Canine |
Tag : |
Fc |
Form : |
Lyophilized from sterile PBS, pH7.4. |
Molecular Mass : |
The recombinant canine ACVR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 344 amino acids and has a predicted molecular mass of 38.6 kDa. The apparent molecular mass of the protein is approximately 68 and 44 kDa in SDS-PAGE under reducing conditions. |
Protein length : |
Met1-Glu123 |
Endotoxin : |
< 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : |
(32.9+66.0) % as determined by SDS-PAGE |
Stability : |
Samples are stable for up to twelve months from date of receipt at -70℃ |
Storage : |
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : |
Hardcopy of COA with reconstitution instruction is sent along with the products. |