Recombinant Canine IGF1R Protein, His-tagged

• Cat.No.: IGF1R-50C
• Product Overview: Recombinant Canine IGF1R Protein, fused to His-tag, was expressed in HEK293.

Specification

• Description: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Source: HEK293
• Species: Canine
• Tag: His
• Form: PBS, pH7.4
• Molecular Mass: 103 kDa
• AA Sequence: EICGPGIDIRNDYQQLKRLENCTVI EGYLHILLISKAEDYRSYRFPKLTV ITEYLLLFRVAGLESLGDLFPNLTV IRGWKLFYNYALVIFEMTNLKDIGL YNLRNITRGAIRIEKNADLCYLSTV DWSLILDAVSNNYIVGNKPPKECGD LCPGTMEEKPLCEKTTINNEYNYRC WTTNRCQKMCPSACGKRACTENNEC CHPECLGSCSAPDNDTACVACRHYY YAGVCVPTCPPNTYRFEGWRCVDRD FCANIPSAESSDSEGFVIHDGECMQ ECPSGFIRNGSQSMYCIPCEGPCPK VCEEEKKTKTIDSVTSAQMLQGCTI FKGNLLINIRRGNNIASELENFMGL IEVVTGYVKIRHSHALVSLSFLKNL RQILGEEQLEGNYSFYVLDNQNLQQ LWDWDHRNLTIKAGKMYFAFNPKLC VSEIYRMEEVTGTKGRQSKGDINTR NNGERASCESDVLHFTSTTTWKNRI IITWHRYRPPDYRDLISFTVYYKEA PFKNVTEYDGQDACGSNSWNMVDVD LPPNKDVEPGILLHGLKPWTQYAVY VKAVTLTMVENDHIRGAKSEILYIR TNASVPSIPLDVLSASNSSSQLIVK WNPPSLPNGNLSYYIVRWQRQPQDS YLYRHNYCSKDKIPIRKYADGTIDV EEVTENPKTEVCGGEKGPCCACPKT EAEKQAEKEEAEYRKVFENFLHNSI FVPRPERKRRDVTQVTNTTMSSRSR NTTVVDTYNITDPEELETEYPFFES RVDNKERTVISNLRPFTLYRIDIHS CNHEAEKLGCSASNFVFARTMPAEG ADDIPGPVTWESRPENSIFLKWPEP ENPNGLILMYEIKYGSQIEDQRECV SRQEYRKYGGAKLNRLNPGNYTARI QATSLSGNGSWTDPVFFYVPAKITY ENHHHHHH
• Purity: >90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.25 mg/ml

Gene Information

• Gene Name: IGF1R insulin like growth factor 1 receptor [ Homo sapiens (human) ]
• Official Symbol: IGF1R
• Synonyms: IGFR; CD221; IGFIR; JTK13
• Gene ID: 3480
• mRNA Refseq: NM_000875
• Protein Refseq: NP_000866
• MIM: 147370
• UniProt ID: P56950