Recombinant Cat CSF1R Protein (20-514 aa), His-SUMO-tagged

• Cat.No.: CSF1R-429C
• Product Overview: Recombinant Cat CSF1R Protein (20-514 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Full Length.

Specification

• Description: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hatopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and fale fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of mbrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family mbers, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family mbers STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
• Source: E. coli
• Species: Cat
• Tag: His&SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 70.8 kDa
• Protein length: 20-514 aa
• AA Sequence: VPVIQPSGPELVVEPGTTVTLRCVG NGSVEWDGPISPHWNLDLDPPSSIL TTNNATFQNTGTYHCTEPGNPQGGN ATIHLYVKDPARPWKVLAQEVTVLE GQDALLPCLLTDPALEAGVSLVRVR GRPVLRQTNYSFSPWHGFTIHKAKF IENHVYQCSARVDGRTVTSMGIWLK VQKDISGPATLTLEPAELVRIQGEA AQIVCSASNIDVNFDVSLRHGDTKL TISQQSDFHDNRYQKVLTLNLDHVS FQDAGNYSCTATNAWGNHSASMVFR VVESAYLNLTSEQSLLQEVTVGEKV DLQVKVEAYPGLESFNWTYLGPFSD YQDKLDFVTIKDTYRYTSTLSLPRL KRSEAGRYSFLARNAGGQNALTFEL TLRYPPEVRVTMTLINGSDTLLCEA SGYPQPSVTWVQCRSHTDRCDESAG LVLEDSHSEVLSQVPFHEVIVHSLL AIGTLEHNRTYECRAFNSVGNSSQT FWPISIGAHTQLPDELLFTP
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: CSF1R colony stimulating factor 1 receptor [ Felis catus ]
• Official Symbol: CSF1R
• Synonyms: CSF1R; c-fms; CSF-1-R; CSF-1 receptor; CSF1; M-CSF; CSF-1R; M-CSF-R
• Gene ID: 493706
• mRNA Refseq: NM_001009231
• Protein Refseq: NP_001009231
• UniProt ID: P13369

Reviews

01/09/2022

With its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.

10/30/2017

This variety allows me to select the most appropriate option based on the specific requirements of my research.

03/10/2017

the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the CSF1R protein, which is essential for obtaining accurate and consistent results.

Q&As

Are there any FDA-approved drugs targeting CSF1R for clinical use?

Yes, drugs like pexidartinib have been approved for the treatment of certain rare tumors called tenosynovial giant cell tumors (TGCT) that overexpress CSF1R.

How can CSF1R inhibitors impact the tumor microenvironment?

CSF1R inhibitors can modulate the tumor microenvironment by reducing the number of tumor-associated macrophages and promoting an anti-tumor immune response.

Can CSF1R inhibitors be used in combination with other cancer treatments?

Yes, CSF1R inhibitors are often used in combination with chemotherapy and immunotherapy to enhance treatment effectiveness.

What are the potential clinical applications of CSF1R inhibitors?

CSF1R inhibitors are being investigated for cancer therapy to block tumor-promoting macrophages and slow down cancer progression.

Can CSF1R inhibitors be used to treat neurodegenerative diseases?

Research is ongoing, and CSF1R inhibitors are being explored as a potential therapy for neurodegenerative diseases, but no FDA-approved treatments currently exist.